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Pharmaceutical Intermediate Aricept Donepezil Powder CAS 120014-06-4

Pharmaceutical Intermediate Aricept Donepezil Powder CAS 120014-06-4

Aricept Donepezil Powder for Brain Protect CAS: 120014-06-4 MOQ:10g Email: lesley@chembj.com Skype: lesley_1817 WhatsApp: +86 18123797637

Products Specifications:

What is Donepezil?

Donepezil is an oral medication used to treat Alzheimer's disease. It belongs to a class of drugs called cholinesterase inhibitors that also includes tacrine (Cognex).


How does it work?

Donepezil inhibits acetylcholinesterase, an enzyme responsible for the destruction of one neurotransmitter, acetylcholine. This leads to increased concentrations of acetylcholine in the brain, and the increased concentrations are believed to be responsible for the improvement seen during treatment with donepezil.


Donepezil COA

TEST ITEMSPECIFICATIONRESULT
AppearanceOff white to white crystalline powderComplies
Solubilityfreely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane
Complies
Identification(1)By IR absorption ,To match with working
standard
Complies
(2) The retention time of the major peak of
the sample should accord with that of the
working standard.
Complies
(3) Test for chlorides. Reponds to the test
for Chlorides.
Complies
PH4.0-7.06.10
Residue on ignition≤0.1%0.03%
Related substanceAny Unkonwn single impurity≤0.3%
Total ≤0.5%
0.04%
0.18%
Heavy metal≤10ppm<10ppm
Residual SolventsMethanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%
Not detected
Not detected
Not detected
Not detected
Not detected
Loss on drying≤0.5%0.20%
AssayOn dried base, C24H29NO3·HCl
should be 98.0% to 102.0%
100.20%
Conclusion: The product complies to Enterprise standard


Usage:

Donepezil is used to treat confusion (dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to function. This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain.


Recommend Dosing:

The recommended starting dosage of Donepezil hydrochloride is 5 mg administered once per day in the evening, just prior to retiring. The maximum recommended dosage of Donepezil hydrochloride in patients with mild to moderate Alzheimer's disease is 10 mg per day. A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.


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PACKING
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 5kg/carton(1kg net weight, 1.1kg gross weight, packed in five aluminum foil bag)
3) 25kg/drum (25kg net weight, 28kg gross weight; packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)


DELIVERY
1) ≤50kgs Send by DHL, EMS, FEDEX, TNT.
2) ≥50kgs Ship by air.
3) ≥200kgs Ship by sea.


Please contact me if you are interested in our product.

Contact Information:

Email: lesley@chembj.com

Skype: lesley_1817

WhatsApp:+86 18123797637

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